American and Polish scientists, reporting Oct. 16 in the journal Science Advances, laid out a novel rationale for COVID-19 drug create — blocking off a molecular “scissor” that the virus uses for virus manufacturing and to disable human proteins wanted to the immune response.
SARS-CoV-2-PLpro promotes infection by sensing and processing every viral and human proteins, stated senior writer Shaun Okay. Olsen, PhD, companion professor of biochemistry and structural biology in the Joe R. and Teresa Lozano Long College of Medication at UT Smartly being San Antonio.
“This enzyme executes a double-whammy,” Dr. Olsen stated. “It stimulates the release of proteins that are wanted for the virus to replicate, and it also inhibits molecules called cytokines and chemokines that signal the immune system to attack the infection,” Dr. Olsen stated.