• Sun. Oct 25th, 2020

Antioxidant Enzyme Catalase Can also fair Lend a hand Take care of COVID-19

Antioxidant Enzyme Catalase Can also fair Lend a hand Take care of COVID-19
Catalase, a naturally occurring enzyme continuously former worldwide in meals production and as a dietary supplement, holds capability as a low-cost therapeutic drug to treat the signs of the COVID-19 illness and suppress the replication of the SARS-CoV-2 virus interior the physique.

Proposed mechanism of action and synthesis of catalase nanocapsules: (A) a schematic illustrating that an elevated level of reactive oxygen species (ROS) causes oxidative injury, promotes viral replication, and triggers cytokine storm syndrome in COVID-19 patients; (B) the reaction pathways of ROS, suggesting that eliminating hydrogen peroxide is the key to minimizing the formation of downstream ROS; (C) the synthesis of catalase nanocapsules by in situ polymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC) and N,N’-methylenebisacrylamide (BIS) around individual catalase molecules exhibiting improved stability and circulation half-life. Image credit: Qin et al, doi: 10.1002/adma.202004901.

Proposed mechanism of action and synthesis of catalase nanocapsules: (A) a schematic illustrating that an elevated stage of reactive oxygen species (ROS) causes oxidative damage, promotes viral replication, and triggers cytokine storm syndrome in COVID-19 patients; (B) the response pathways of ROS, suggesting that taking away hydrogen peroxide is the important to minimizing the formation of downstream ROS; (C) the synthesis of catalase nanocapsules by in situ polymerization of two-methacryloyloxyethyl phosphorylcholine (MPC) and N,N’-methylenebisacrylamide (BIS) spherical particular person catalase molecules exhibiting improved stability and circulation half of-existence. Describe credit score: Qin et al, doi: 10.1002/adma.202004901.

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